Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP)/Neuropeptide Y (NPY)/GABA neurons produce anorexigenic and orexigenic neuropeptides and neurotransmitters. and express the long signaling form of the leptin receptor (LepRb). Despite progress in the understanding of LepRb signaling and function. https://www.duospiritalis.com/