Substitution at R3 using a halogen or alkoxy group (74f–74i) brought about a slight rise in cellular potency with the halide analogs (74g–h) demonstrating optimum the potency from the group. Additional optimization led to the invention of 74i–j, with 74k as by far the most Energetic compound in the sequence https://indazoleproducts66320.blogzag.com/75527619/indicators-on-indazole-amide-you-should-know